Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22877114 | 0.98 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL8163321 | 0.87 | GRM5 (0.55) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL8155738 | 0.84 | GRM5 (0.54) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL17404928 | 0.81 | SMN1; SMN2 (0.53) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL28068579 | 0.81 | KDM1A (0.42) | RAB9ANPC1EPHX1LMNAMEN1 | |
| SCHEMBL19891369 | 0.79 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL4909831 | 0.79 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 | |
| SCHEMBL22279371 | 0.78 | NPC1 (0.66) | RAB9ANPC1SMN1; SMN2EPHX2LMNA | |
| SCHEMBL24673320 | 0.77 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8396558 | 0.77 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740584-B1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2008-12-03 | — | — | EP | disclosed |