SCHEMBL1401356

SCHEMBL1401356

CN(C)CC1CCN(C(=O)C(Cc2ccccc2)N(C)C(=O)C(Cc2ccc3ccccc3c2)N(C)C(=O)/C=C/CC(C)(C)N)CC1

nearest known ligand 0.70

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.55
OPRD1 P41143 1/20 0.40
P2RX7 Q99572 1/20 0.37
TACR1 P25103 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL867659 1.00 GHSR (0.55) GHSROPRD1P2RX7TACR1
SCHEMBL867658 1.00 GHSR (0.55) GHSROPRD1P2RX7TACR1
SCHEMBL867797 0.92 GHSR (0.56) GHSROPRD1TACR1
SCHEMBL867796 0.92 GHSR (0.56) GHSROPRD1TACR1
SCHEMBL1401070 0.92 GHSR (0.52) GHSROPRD1TACR1
SCHEMBL1401071 0.92 GHSR (0.52) GHSROPRD1TACR1
SCHEMBL1401210 0.92 GHSR (0.56) GHSROPRD1TACR1
SCHEMBL1401184 0.92 GHSR (0.56) GHSROPRD1TACR1
SCHEMBL1401160 0.89 GHSR (0.60) GHSR
SCHEMBL1401171 0.89 GHSR (0.60) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100824-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2011-03-02 EP disclosed