GHSR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL122833	1.00	20/20
SCHEMBL122945	1.00	20/20
SCHEMBL123874	1.00	20/20
SCHEMBL122516	0.84	20/20
SCHEMBL122760	0.80	20/20
SCHEMBL124058	0.80	20/20
SCHEMBL125321	0.66	20/20
SCHEMBL123504	0.61	20/20
SCHEMBL125587	0.59	20/20
SCHEMBL122725	0.55	20/20
SCHEMBL125305	0.53	20/20
SCHEMBL124753	0.73	19/20
SCHEMBL125183	0.72	19/20
SCHEMBL124336	0.68	19/20
SCHEMBL124210	0.62	19/20
SCHEMBL125417	0.56	15/20
Examorelin (SCHEMBL26959)	0.60	13/20
SCHEMBL74394	0.72	8/20
SCHEMBL74025	0.65	8/20
SCHEMBL91248	0.64	8/20

Clinical trials — most relevant to GHSR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth	PHASE4	UNKNOWN
Growth Hormone and Glucose Metabolism	PHASE4	COMPLETED
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency	PHASE3	COMPLETED
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment	PHASE1/PHASE2	RECRUITING
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia	PHASE2	COMPLETED
Growth Hormone Treatment in Children With Phelan McDermid Syndrome	PHASE2	COMPLETED
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.	PHASE2	COMPLETED
Growth Hormone in a Patient With a Dominant-Negative GHR Mutation	PHASE2	ACTIVE_NOT_RECRUITING
Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF	PHASE1/PHASE2	UNKNOWN
Ghrelin and Gastric Emptying in Children With Functional Dyspepsia	nan	COMPLETED
An Open-label, Multi-center, Expanded Treatment Protocol of Pasireotide LAR in Patients With Acromegaly	nan	APPROVED_FOR_MARKETING
Growth and Metabolic Response to GH and GnRHa Treatment Versus GH Alone in Boys Born SGA.	nan	COMPLETED
Acylated Ghrelin Response to Acute Exercise in Obesity	nan	COMPLETED
Pharmacokinetics of Ghrelin	nan	COMPLETED
Effects of Short-term Growth Hormone in HIV-infected Patients	nan	COMPLETED
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)	nan	COMPLETED
A Study to Assess Growth in Children With Idiopathic Short Stature	nan	RECRUITING
Growth Hormone Secretagogue MK-0677 Effect on IGF-1 Levels in ESRD Patients	nan	COMPLETED
Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly	nan	COMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine	nan	COMPLETED
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle	nan	UNKNOWN
Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis	nan	UNKNOWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Epidemiology of Acromegaly in Denmark 1991-2010	nan	UNKNOWN
Validation of Two Measures for Growth Hormone Deficiency in Children, the Treatment Related Impact Measure of Childhood Growth Hormone Deficiency (TRIM-CGHD) and the Treatment Burden Measure of Childhood Growth Hormone Deficiency (TB-CGHD)	nan	COMPLETED
Macronutrient Regulation of Ghrelin and Peptide YY	nan	COMPLETED
The Effects of Growth Hormone Treatment Discontinuation in Adults on Metabolic Profile, Body Composition and Quality Of Life (GAMBOL Study)	nan	UNKNOWN
Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly	nan	COMPLETED
Consequence of Lifetime Isolated Growth Hormone Deficiency	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GHSR binder may also engage these)

Protein	Name	Similarity
A5A4K9	—	1.000	A5A4K9 →
Q95254	—	1.000	Q95254 →
O08725	—	1.000	O08725 →
A5A4L1	—	1.000	A5A4L1 →
Q99P50	—	0.998	Q99P50 →
P34970	—	0.957	P34970 →
P11616	—	0.957	P11616 →
ADORA1	Adenosine receptor A1	0.953	landscape →
Q60612	—	0.953	Q60612 →
Q5RF57	—	0.952	Q5RF57 →
GRPR	Gastrin-releasing peptide receptor	0.952	landscape →
P25099	—	0.951	P25099 →
P60895	—	0.949	P60895 →
P60894	—	0.949	P60894 →
SSTR1	Somatostatin receptor type 1	0.948	landscape →
B2ZI34	—	0.947	B2ZI34 →
P60893	—	0.947	P60893 →
Q5D0K2	—	0.947	Q5D0K2 →
P21729	—	0.947	P21729 →
P47745	—	0.947	P47745 →
Q9TTQ9	—	0.946	Q9TTQ9 →
MLNR	Motilin receptor	0.945	landscape →
P24053	—	0.945	P24053 →
P33534	—	0.945	P33534 →
P28190	—	0.945	P28190 →
Q49LX5	—	0.945	Q49LX5 →
Q9I919	—	0.945	Q9I919 →
Q9NYM4	—	0.944	Q9NYM4 →
Q5RBG7	—	0.943	Q5RBG7 →
P52500	—	0.943	P52500 →