Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.78 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 4/20 | 0.76 |
| ▸ | MYC | P01106 | 1/20 | 0.69 |
| ▸ | MAX | P61244 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | GLA | P06280 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | CASP1 | P29466 | 2/20 | 0.64 |
| ▸ | CASP7 | P55210 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | FUBP1 | Q96AE4 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277995 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1718137 | 0.88 | KDM4E (0.76) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL30382020 | 0.87 | KDM4E (0.82) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1718395 | 0.86 | KDM4E (0.78) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1718140 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1718669 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL4197490 | 0.83 | KDM4E (0.74) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL14725134 | 0.82 | MYC (1.00) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1719581 | 0.82 | MAPT (0.72) | KDM4EALDH1A1APOBEC3AHTTMAPT | |
| SCHEMBL1718874 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1APOBEC3AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |