Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | GAA | P10253 | 4/20 | 0.75 |
| ▸ | MYC | P01106 | 1/20 | 0.70 |
| ▸ | MAX | P61244 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | CASP1 | P29466 | 2/20 | 0.69 |
| ▸ | CASP7 | P55210 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718140 | 0.88 | KDM4E (0.77) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL30612821 | 0.86 | ALDH1A1 (0.79) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL1718423 | 0.85 | MYC (0.81) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL1718395 | 0.84 | KDM4E (0.78) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL1718137 | 0.83 | KDM4E (0.76) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL14014121 | 0.83 | KDM4E (0.78) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL14725134 | 0.82 | MYC (1.00) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL1719319 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL1719493 | 0.82 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTGAAMYC | |
| SCHEMBL3277995 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1MAPTGAAMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |