Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 3/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014087 | 0.96 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14014039 | 0.96 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14014051 | 0.95 | KDM4E (0.74) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL312337 | 0.90 | KDM4E (0.80) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14014044 | 0.89 | KDM4E (0.82) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL312422 | 0.89 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL312531 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL13731642 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20435602 | 0.82 | NPC1 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL14014048 | 0.81 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |