Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | HTR1E | P28566 | 1/20 | 0.67 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22266637 | 0.88 | LMNA (0.72) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL28593334 | 0.85 | GAA (0.71) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL16383892 | 0.84 | KDM4E (0.74) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL6628661 | 0.82 | HDAC1 (0.71) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL19242711 | 0.82 | NPSR1 (1.00) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL13842115 | 0.80 | HDAC1 (0.68) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL28583860 | 0.79 | KDM4E (0.63) | LMNANPSR1HDAC1CYP2C9CYP2C19 | |
| SCHEMBL2861856 | 0.78 | ERCC1 (0.68) | LMNANPSR1CYP2C9CYP2C19MEN1 | |
| SCHEMBL24444629 | 0.78 | LMNA (0.58) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16639040 | 0.77 | HDAC4 (0.71) | LMNANPSR1HDAC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ADAMS JERRY LEROY | 2008-11-20 | — | — | US | disclosed |
| US-7427623-B2 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-23 | — | — | US | disclosed |
| US-7427623-B2 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | TIE1, TEK, KDR | LMNA 4131/4885NPSR1 3862/4885HDAC1 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.