Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MARS1 | P56192 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014333 | 0.92 | KDM4E (0.57) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014251 | 0.91 | KDM4E (0.69) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014190 | 0.90 | KDM4E (0.59) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014314 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1TP53CYP3A4CYP2C9 | |
| SCHEMBL14014238 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014319 | 0.85 | TP53 (0.57) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014287 | 0.85 | TP53 (0.57) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014243 | 0.85 | KDM4E (0.78) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014201 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL14014244 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1TP53MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |