Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014201 | 0.93 | KDM4E (0.60) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014190 | 0.92 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014229 | 0.92 | KDM4E (0.58) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014245 | 0.91 | KDM4E (0.57) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014279 | 0.90 | MAPT (0.59) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014324 | 0.89 | KDM4E (0.66) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014241 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014333 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014334 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDCYP3A4 | |
| SCHEMBL14014249 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1MAPTHPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |