Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217405 | 0.84 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14647529 | 0.81 | MAP2K1 (0.54) | HTTMAP2K1MAP2K2MAPTMAP2K5 | |
| SCHEMBL220490 | 0.80 | MAP2K1 (0.55) | HTTMAP2K1MAP2K2 | |
| SCHEMBL221014 | 0.79 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL221013 | 0.79 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL219481 | 0.78 | IDO1 (0.41) | HTTMAP2K1MAP2K2MAPTMAP2K5 | |
| SCHEMBL3010504 | 0.73 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL218724 | 0.73 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL27765754 | 0.73 | MAP2K1 (0.37) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL218385 | 0.73 | MAP2K1 (0.52) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140553-A2 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |