Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219481 | 0.85 | IDO1 (0.41) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL217405 | 0.84 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL218385 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14015154 | 0.75 | MAP2K1 (0.49) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL220560 | 0.74 | MAP2K1 (0.51) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL13210468 | 0.73 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14014336 | 0.73 | HTT (0.37) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL3010504 | 0.73 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL218724 | 0.73 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14647529 | 0.73 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101563338-A | MAPK/ERK kinase inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2009-10-21 | — | — | CN | claimed |
| CN-101563338-A | MAPK/ERK kinase inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2009-10-21 | — | — | CN | disclosed |