Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.57 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014226 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014349 | 0.94 | KDM4E (0.72) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014326 | 0.93 | KDM4E (0.70) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014338 | 0.91 | KDM4E (0.59) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014317 | 0.91 | ALDH1A1 (0.59) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014225 | 0.91 | KDM4E (0.59) | ALDH1A1KDM4EMCL1MDM2PTGS1 | |
| SCHEMBL14014298 | 0.91 | MCL1 (0.66) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014235 | 0.90 | KDM4E (0.63) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014350 | 0.90 | KDM4E (0.63) | ALDH1A1KDM4EMCL1MDM2BCL2 | |
| SCHEMBL14014296 | 0.90 | MARS1 (0.54) | ALDH1A1KDM4EMCL1MDM2BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |