Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.48 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014319 | 0.91 | TP53 (0.57) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014301 | 0.89 | TP53 (0.58) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014246 | 0.88 | KDM4E (0.59) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014191 | 0.88 | KDM4E (0.62) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014272 | 0.87 | TP53 (0.58) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014274 | 0.87 | KDM4E (0.70) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014254 | 0.87 | KDM4E (0.73) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014357 | 0.86 | ALDH1A1 (0.59) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014239 | 0.84 | KDM4E (0.57) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14014273 | 0.84 | KDM4E (0.65) | MAPTLMNATP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |