Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943669 | 0.87 | MAPK14 (0.52) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL2943674 | 0.87 | MAPK14 (0.52) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL2948114 | 0.87 | MAPK14 (0.52) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14014401 | 0.86 | MAPK14 (0.64) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL29830087 | 0.86 | MAPK14 (0.70) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14014098 | 0.86 | MAPK14 (0.70) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14595094 | 0.84 | MAPK14 (0.59) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL5115734 | 0.82 | MAPK14 (0.60) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14511933 | 0.82 | MAPK14 (0.58) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14039213 | 0.80 | MAPK14 (0.57) | MAPK14MAPK8MAPK9MAPK10MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | P2RX6, P2RX1, P2RX7 | MAPK14 4250/4885MAPK8 3523/4885MAPK9 1204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.