Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | WEE1 | P30291 | 8/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014623 | 0.96 | MAPK14 (0.63) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL29593316 | 0.95 | MAPK14 (0.66) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL5120872 | 0.95 | MAPK14 (0.66) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL14014883 | 0.92 | MAPK14 (0.65) | MAPK14SRCEGFRFGFR1WEE1 | |
| SCHEMBL14014672 | 0.88 | MAPK14 (0.69) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL14014723 | 0.86 | MAPK14 (0.59) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL5107289 | 0.85 | SRC (0.63) | MAPK14SRCEGFRFGFR1ABL1 | |
| SCHEMBL29594501 | 0.85 | SRC (0.71) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL5120281 | 0.85 | SRC (0.71) | MAPK8MAPK14SRCEGFRFGFR1 | |
| SCHEMBL5120866 | 0.84 | MAPK14 (0.61) | MAPK8MAPK14FGFR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | P2RX6, P2RX1, P2RX7 | MAPK8 3523/4885MAPK14 4250/4885SRC 2796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.