Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654299 | 0.94 | LMNA (0.38) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL14469041 | 0.94 | LMNA (0.38) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4654301 | 0.94 | LMNA (0.38) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4655114 | 0.91 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4655111 | 0.91 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL14016146 | 0.91 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4655064 | 0.90 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL14469135 | 0.90 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4655063 | 0.90 | LMNA (0.36) | LMNATP53NPSR1MAPTMEN1 | |
| SCHEMBL4654312 | 0.82 | LMNA (0.38) | LMNATP53NPSR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740568-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE. | SMITHKLINE BEECHAM CORP (US) | 2008-11-26 | — | — | EP | disclosed |