Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15985246 | 0.86 | CYP2D6 (0.60) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL29598556 | 0.86 | GAA (0.61) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL31645775 | 0.85 | CYP2D6 (0.59) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| Oxalic Acid SCHEMBL20798190 | 0.83 | CYP2D6 (0.54) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL14016365 | 0.79 | GAA (0.46) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL27798357 | 0.79 | SIGMAR1 (0.62) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL11707747 | 0.78 | GAA (0.61) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL4588336 | 0.78 | TSHR (0.40) | SIGMAR1GAATSHRCYP2D6MEN1 | |
| SCHEMBL4292159 | 0.77 | CYP2D6 (0.76) | SIGMAR1TSHRCYP2D6MEN1KMT2A | |
| SCHEMBL1426377 | 0.77 | CYP2D6 (0.67) | SIGMAR1GAATSHRCYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| WO-2007027734-A2 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2007-03-08 | — | — | WO | disclosed |