Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.55 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017710 | 0.93 | MET (0.54) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL4811602 | 0.90 | AAK1 (0.63) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL4821156 | 0.90 | MET (0.58) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL14017677 | 0.87 | AAK1 (0.57) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL14017676 | 0.87 | AAK1 (0.57) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL14017679 | 0.84 | AAK1 (0.54) | METAAK1NTRK1 | |
| SCHEMBL4817297 | 0.83 | MET (0.61) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL4819894 | 0.82 | MET (0.62) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL4819515 | 0.82 | MET (0.57) | METAAK1NTRK1EGFRERBB2 | |
| SCHEMBL4822868 | 0.80 | MET (0.56) | METAAK1NTRK1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7173031-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | disclosed |