Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.52 |
| ▸ | RARG | P13631 | 6/20 | 0.52 |
| ▸ | RARA | P10276 | 5/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | VDR | P11473 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017812 | 0.90 | RARB (0.53) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL14159883 | 0.87 | RARB (0.68) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL2594345 | 0.82 | RARB (0.75) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL4666958 | 0.82 | RARB (0.75) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL14018613 | 0.82 | RARB (0.60) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL10842924 | 0.81 | RARB (0.55) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL10842927 | 0.81 | RARB (0.55) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL14159774 | 0.80 | RARB (0.52) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL1615332 | 0.80 | RARB (0.72) | RARBRARGRARAPTPN1VDR | |
| SCHEMBL1615774 | 0.80 | RARB (0.72) | RARBRARGRARAPTPN1VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324970-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |