Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | CALCA | P06881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14018828 | 0.98 | MAPK14 (0.38) | MAPK14BRD4ALOX5APFEN1MAPK11 | |
| SCHEMBL14019019 | 0.86 | MAPK14 (0.40) | MAPK14BRD4MAPK11CALCA | |
| SCHEMBL4842618 | 0.83 | MAPK14 (0.37) | MAPK14 | |
| SCHEMBL4837598 | 0.82 | ALDH1A1 (0.42) | MAPK14 | |
| SCHEMBL4833720 | 0.80 | KDM4E (0.38) | MAPK14 | |
| SCHEMBL4837825 | 0.80 | MAPK14 (0.39) | MAPK14 | |
| SCHEMBL4836118 | 0.80 | MAPK14 (0.36) | MAPK14MAPK11 | |
| SCHEMBL4840914 | 0.80 | MAPK14 (0.48) | MAPK14MAPK11 | |
| SCHEMBL14018800 | 0.80 | CNR2 (0.36) | MAPK14 | |
| SCHEMBL4832890 | 0.79 | LRRK2 (0.39) | MAPK14CDK2MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |