Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.59 |
| ▸ | CHUK | O15111 | 6/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL552463 | 0.88 | IKBKB (0.76) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL14018309 | 0.83 | IKBKB (0.68) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL619236 | 0.82 | IKBKB (0.70) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL619237 | 0.82 | IKBKB (0.59) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL14626680 | 0.81 | IKBKB (0.54) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL14627025 | 0.80 | IKBKB (0.53) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5023366 | 0.79 | IKBKB (0.50) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL552970 | 0.79 | IKBKB (0.77) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL552201 | 0.79 | IKBKB (0.76) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5023382 | 0.79 | IKBKB (0.56) | IKBKBCHUKBTKAURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703905-B1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-11-12 | — | — | EP | disclosed |