Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 6/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021028 | 0.89 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL13049909 | 0.88 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL14021023 | 0.87 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL14021032 | 0.86 | PDGFRA (0.62) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL4062045 | 0.86 | CAMK2D (0.78) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL4072590 | 0.85 | PIK3CA (0.70) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL14021178 | 0.85 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL4070306 | 0.85 | MAPK8 (0.77) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL14021261 | 0.85 | PIK3CA (0.59) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB | |
| SCHEMBL14021027 | 0.85 | CAMK2D (0.67) | PIK3CAPIK3CBPIK3CGCAMK2DIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |