Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 3/20 | 0.71 |
| ▸ | PLK1 | P53350 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 10/20 | 0.63 |
| ▸ | BCR | P11274 | 10/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.63 |
| ▸ | PRKCA | P17252 | 5/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | PRKCH | P24723 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.59 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021038 | 0.90 | CAMK2D (0.71) | CAMK2DJAK2ABL1BCRPDGFRB | |
| SCHEMBL14021028 | 0.90 | PIK3CA (0.64) | CAMK2DPLK1JAK2ABL1BCR | |
| SCHEMBL14021044 | 0.88 | PIK3CG (0.64) | CAMK2DJAK2ABL1BCRPDGFRB | |
| SCHEMBL9519 | 0.87 | ABL1 (0.74) | CAMK2DJAK2ABL1BCRPDGFRB | |
| SCHEMBL14021027 | 0.86 | CAMK2D (0.67) | CAMK2DPLK1JAK2ABL1BCR | |
| SCHEMBL14021033 | 0.86 | AURKA (0.62) | CAMK2DPLK1JAK2ABL1BCR | |
| SCHEMBL14021026 | 0.85 | PDGFRB (0.63) | CAMK2DPLK1JAK2ABL1BCR | |
| SCHEMBL14021032 | 0.85 | PDGFRA (0.62) | CAMK2DJAK2ABL1BCRPDGFRB | |
| SCHEMBL4905540 | 0.84 | ABL1 (0.62) | CAMK2DPLK1JAK2ABL1BCR | |
| SCHEMBL10208 | 0.84 | ABL1 (0.82) | ABL1BCRPDGFRBPDGFRAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |