Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021582 | 0.92 | GAA (0.58) | CYP2C19CDK2CDK1KDM4EHPGD | |
| SCHEMBL4806626 | 0.90 | JAK2 (0.49) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL8311614 | 0.89 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL14021080 | 0.89 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL8311018 | 0.89 | JAK2 (0.61) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL14021077 | 0.88 | CDK2 (0.58) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL14021629 | 0.88 | JAK2 (0.54) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL8312148 | 0.87 | CDK1 (0.62) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL1512786 | 0.87 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGCDK2CDK1 | |
| SCHEMBL14021410 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |