Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 4/20 | 0.43 |
| ▸ | CHUK | O15111 | 3/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | OPA1 | O60313 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311614 | 0.92 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL8312575 | 0.89 | JAK2 (0.49) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021407 | 0.87 | JAK2 (0.51) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021228 | 0.87 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL4806626 | 0.87 | JAK2 (0.49) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL8311018 | 0.82 | JAK2 (0.61) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021080 | 0.82 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL8312432 | 0.81 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021629 | 0.81 | JAK2 (0.54) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL8312148 | 0.81 | CDK1 (0.62) | PIK3CAPIK3CBPIK3CGJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |