Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095271 | 0.82 | MAPT (0.59) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14022727 | 0.80 | PIK3CD (0.48) | ALDH1A1HPGDPIM1KDM4EMEN1 | |
| SCHEMBL14021886 | 0.80 | PIK3CB (0.52) | ALDH1A1GAAHSD17B10 | |
| SCHEMBL14021883 | 0.78 | PIK3CB (0.43) | NPC1MAPTALDH1A1RAB9A | |
| SCHEMBL14021881 | 0.77 | PIK3CA (0.42) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3087828 | 0.76 | ALDH1A1 (0.56) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14021877 | 0.76 | PIK3CA (0.43) | ALDH1A1GAAHPGDKDM4E | |
| SCHEMBL13276521 | 0.74 | ALDH1A1 (0.60) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3087886 | 0.73 | ALDH1A1 (0.55) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL12812381 | 0.72 | ALDH1A1 (0.60) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |