Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clopidogrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 known ✓ | Q9H244 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.98 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.98 |
| ▸ | THRB | P10828 | 1/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | CES1 | P23141 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clopidogrel SCHEMBL19148648 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL29793709 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL14009483 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL30388817 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL1031641 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL5567933 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL1031319 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL754557 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL4769 | 0.99 | ABCB11 (1.00) | ABCB11OPRM1ADRA2ACYP2B6DRD1 | |
| Clopidogrel SCHEMBL1130036 | 0.98 | ABCB11 (0.98) | ABCB11OPRM1ADRA2ACYP2B6DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070048370-A1 | Pharmaceutical formulation for salts of monobasic acids with clopidogrel | HELM AG (DE) | 2007-03-01 | — | — | US | claimed |
| EP-1606231-A1 | PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS | Nadkarni, Sunil Sadanand (IN) | 2005-12-21 | — | — | EP | claimed |
| WO-2004074215-A1 | PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS | NADKARNI SUNIL SADANAND (IN) | 2004-09-02 | — | — | WO | claimed |
| EP-2303233-B1 | SOLID ORAL DOSAGE FORM CONTAINING ANTI-PLATELET AGENT CLOPIDOGREL AND METHOD FOR THE PREPARATION THEREOF | PHARMATHEN SA (GR) | 2012-06-20 | — | — | EP | disclosed |
| EP-2303233-A1 | SOLID ORAL DOSAGE FORM CONTAINING ANTI-PLATELET AGENT CLOPIDOGREL AND METHOD FOR THE PREPARATION THEREOF | Pharmathen S.A. (GR) | 2011-04-06 | — | — | EP | disclosed |
| EP-2291177-A2 | STABLE PHARMACEUTICAL COMPOSITIONS AND THEIR PROCESSES FOR PREPARATION SUITABLE FOR INDUSTRIAL SCALE | Farmaprojects, S.A. (ES) | 2011-03-09 | — | — | EP | disclosed |
| WO-2010009745-A1 | SOLID ORAL DOSAGE FORM CONTAINING ANTI-PLATELET AGENT CLOPIDOGREL AND METHOD FOR THE PREPARATION THEREOF | PHARMATHEN S.A. (GR) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009135646-A2 | STABLE PHARMACEUTICAL COMPOSITIONS AND THEIR PROCESSES FOR PREPARATION SUITABLE FOR INDUSTRIAL SCALE | FARMAPROJECTS, SA (ES) | 2009-11-12 | — | — | WO | disclosed |
| EP-2001449-A2 | MODIFIED RELEASE CLOPIDOGREL FORMULATION | CADILA HEALTHCARE LTD. (IN) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007113857-A2 | MODIFIED RELEASE CLOPIDOGREL FORMULATION | CADILA HEALTHCARE LIMITED (IN) | 2007-10-11 | — | — | WO | disclosed |
| US-20070048370-A1 | Pharmaceutical formulation for salts of monobasic acids with clopidogrel | HELM AG (DE) | 2007-03-01 | — | — | US | disclosed |
| EP-1682096-A1 | PROCESS FOR PREPARING CLOPIDOGREL COMPOSITIONS | Sandoz AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| EP-1606231-A1 | PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS | Nadkarni, Sunil Sadanand (IN) | 2005-12-21 | — | — | EP | disclosed |
| WO-2005048992-A1 | PROCESS FOR PREPARING CLOPIDOGREL COMPOSITIONS | SANDOZ AG (CH) | 2005-06-02 | — | — | WO | disclosed |
| WO-2004074215-A1 | PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS | NADKARNI SUNIL SADANAND (IN) | 2004-09-02 | — | — | WO | disclosed |