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SCHEMBL14022261

SCHEMBL14022261

COc1cccc(OC)c1-n1c(/C=C/c2cccc(C)c2O)nc2ccccc2c1=O

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 7/20 0.61
▸ TP53 P04637 6/20 0.57
▸ MAPT P10636 3/20 0.57
▸ MEN1 O00255 2/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ HTT P42858 1/20 0.52
▸ THRB P10828 1/20 0.52
▸ POLB P06746 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12553519 0.93 LMNA (0.60) LMNATP53MAPTMEN1KMT2A
SCHEMBL1964825 0.93 LMNA (0.63) LMNATP53MAPTMEN1KMT2A
SCHEMBL1964823 0.93 LMNA (0.63) LMNATP53MAPTMEN1KMT2A
SCHEMBL1963734 0.92 LMNA (0.61) LMNATP53MAPTMEN1KMT2A
SCHEMBL1963736 0.92 LMNA (0.61) LMNATP53MAPTMEN1KMT2A
SCHEMBL14022294 0.89 LMNA (0.58) LMNATP53MAPTMEN1KMT2A
SCHEMBL12566952 0.87 LMNA (0.58) LMNATP53MAPTMEN1KMT2A
SCHEMBL1962642 0.87 TP53 (0.67) LMNATP53MAPTMEN1KMT2A
SCHEMBL1962643 0.87 TP53 (0.67) LMNATP53MAPTMEN1KMT2A
SCHEMBL12553518 0.86 TP53 (0.62) LMNATP53MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008140750-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC. (US) 2008-11-20 — — WO disclosed