Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.76 |
| ▸ | JAK2 | O60674 | 19/20 | 0.76 |
| ▸ | TYK2 | P29597 | 17/20 | 0.76 |
| ▸ | CDK2 | P24941 | 16/20 | 0.76 |
| ▸ | JAK1 | P23458 | 12/20 | 0.76 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022785 | 1.00 | FLT3 (0.76) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL1108253 | 0.86 | FLT3 (1.00) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL14023802 | 0.79 | FLT3 (0.54) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL14023829 | 0.79 | FLT3 (0.54) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL823863 | 0.79 | FLT3 (1.00) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL14022786 | 0.77 | JAK2 (0.73) | FLT3JAK2TYK2CDK2JAK1 | |
| Ct-1578 SCHEMBL1004926 | 0.70 | JAK2 (1.00) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL824102 | 0.70 | JAK2 (0.70) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL20322485 | 0.69 | FLT3 (0.82) | FLT3JAK2TYK2CDK2JAK1 | |
| SCHEMBL19605451 | 0.68 | JAK2 (0.72) | FLT3JAK2TYK2CDK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140420-A2 | PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |