Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.73 |
| ▸ | FLT3 | P36888 | 15/20 | 0.73 |
| ▸ | TYK2 | P29597 | 15/20 | 0.73 |
| ▸ | CDK2 | P24941 | 13/20 | 0.73 |
| ▸ | JAK1 | P23458 | 11/20 | 0.73 |
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108253 | 0.84 | FLT3 (1.00) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14022774 | 0.82 | JAK2 (0.61) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL823863 | 0.77 | FLT3 (1.00) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14022780 | 0.77 | FLT3 (0.76) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14022785 | 0.77 | FLT3 (0.76) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL13676178 | 0.72 | FLT3 (0.55) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14023830 | 0.72 | JAK2 (0.41) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL13675497 | 0.71 | FLT3 (0.54) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL24071979 | 0.68 | JAK2 (0.48) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL824067 | 0.67 | JAK2 (0.80) | JAK2FLT3TYK2CDK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140420-A2 | PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |