Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.59 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 7/20 | 0.51 |
| ▸ | BCR | P11274 | 7/20 | 0.51 |
| ▸ | SRC | P12931 | 4/20 | 0.51 |
| ▸ | PRKCA | P17252 | 3/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737537 | 0.91 | SYK (0.67) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL17573428 | 0.89 | PLK1 (0.56) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL27116530 | 0.87 | PLK1 (0.68) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL14530851 | 0.85 | PLK1 (0.75) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL4732256 | 0.85 | PLK1 (0.59) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL4786087 | 0.84 | PLK1 (0.78) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL4736547 | 0.83 | ABL1 (0.63) | PLK1SYKABL1BCRSRC | |
| SCHEMBL4735323 | 0.82 | PLK1 (0.57) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL2945644 | 0.82 | PLK1 (0.79) | PLK1SYKCAMK2DCDK4CDK2 | |
| SCHEMBL4905928 | 0.82 | PLK1 (0.72) | PLK1SYKCAMK2DCDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140420-A2 | PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |