Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.75 |
| ▸ | ABL1 | P00519 | 5/20 | 0.71 |
| ▸ | BCR | P11274 | 5/20 | 0.71 |
| ▸ | SRC | P12931 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | PRKACA | P17612 | 1/20 | 0.71 |
| ▸ | PRKACG | P22612 | 1/20 | 0.71 |
| ▸ | PRKACB | P22694 | 1/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 3/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | ABL2 | P42684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945644 | 0.95 | PLK1 (0.79) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL823915 | 0.91 | CAMK2D (0.82) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL4737537 | 0.91 | SYK (0.67) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL27116530 | 0.87 | PLK1 (0.68) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL4386919 | 0.87 | ABL1 (0.82) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL4907230 | 0.86 | PLK1 (1.00) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL2944088 | 0.86 | ABL1 (0.64) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL5471964 | 0.85 | ABL1 (0.71) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL4732256 | 0.85 | PLK1 (0.59) | PLK1ABL1BCRSRCEGFR | |
| SCHEMBL14023402 | 0.85 | PLK1 (0.59) | PLK1ABL1BCRSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058628-A1 | HETEROALKYL LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2007-05-24 | — | — | WO | disclosed |