Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.41 |
| ▸ | FLT3 | P36888 | 14/20 | 0.41 |
| ▸ | TYK2 | P29597 | 12/20 | 0.41 |
| ▸ | CDK2 | P24941 | 11/20 | 0.41 |
| ▸ | JAK1 | P23458 | 10/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022774 | 0.74 | JAK2 (0.61) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14022786 | 0.72 | JAK2 (0.73) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL14022734 | 0.69 | JAK2 (0.45) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL13676178 | 0.67 | FLT3 (0.55) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL13675497 | 0.67 | FLT3 (0.54) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL824067 | 0.65 | JAK2 (0.80) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL1075177 | 0.64 | BMPR2 (0.62) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL24071979 | 0.64 | JAK2 (0.48) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL13675518 | 0.62 | FLT3 (0.49) | JAK2FLT3TYK2CDK2JAK1 | |
| SCHEMBL20322485 | 0.62 | FLT3 (0.82) | JAK2FLT3TYK2CDK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140420-A2 | PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |