Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.73 |
| ▸ | FLT3 | P36888 | 19/20 | 0.73 |
| ▸ | TYK2 | P29597 | 17/20 | 0.73 |
| ▸ | JAK1 | P23458 | 15/20 | 0.73 |
| ▸ | JAK3 | P52333 | 15/20 | 0.73 |
| ▸ | CDK2 | P24941 | 14/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | STK16 | O75716 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PRKCB | P05771 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022877 | 0.95 | JAK2 (0.79) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14023004 | 0.91 | JAK2 (0.73) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022997 | 0.89 | JAK2 (0.92) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022844 | 0.85 | JAK2 (1.00) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL1108259 | 0.82 | JAK2 (1.00) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14023904 | 0.81 | JAK2 (0.61) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022845 | 0.81 | JAK2 (0.79) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022891 | 0.81 | JAK2 (0.93) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14022818 | 0.81 | JAK2 (0.79) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL14023949 | 0.81 | JAK2 (0.60) | JAK2FLT3TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |