Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 18/20 | 0.76 |
| ▸ | BRD4 | O60885 | 1/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.63 |
| ▸ | ATR | Q13535 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512915 | 0.86 | FYN (1.00) | FYNPIK3CAATR | |
| SCHEMBL30521838 | 0.86 | FYN (1.00) | FYNPIK3CAATR | |
| SCHEMBL3515271 | 0.85 | FYN (0.74) | FYNBRD4PIK3CAATR | |
| SCHEMBL3514483 | 0.81 | FYN (0.83) | FYNPIK3CAATR | |
| SCHEMBL20485736 | 0.81 | FYN (1.00) | FYN | |
| SCHEMBL2903376 | 0.81 | FYN (0.71) | FYNPIK3CAATR | |
| SCHEMBL16330948 | 0.81 | FYN (1.00) | FYNPIK3CAATR | |
| SCHEMBL18613417 | 0.81 | FYN (1.00) | FYN | |
| SCHEMBL18613675 | 0.79 | FYN (1.00) | FYN | |
| SCHEMBL23571215 | 0.79 | BRD4 (1.00) | FYNBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008138889-A2 | 3, 6-DISUBSTITUTED-IMIDAZO [1, 2-B] PYRIDAZINES AND 3, 5-DISUBSTITUTED PYRAZOLO[1, 5-A] PYRIMIDINES AS PHOSPHATIDYLINOSITOL-3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | disclosed |