Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.55 |
| ▸ | BRAF | P15056 | 7/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14024790 | 0.86 | PIK3CA (0.70) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2848159 | 0.83 | CSF1R (0.81) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2840488 | 0.83 | CSF1R (0.56) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2846759 | 0.82 | CSF1R (0.55) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2846761 | 0.82 | CSF1R (0.55) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL14024725 | 0.80 | CYP3A4 (0.48) | PIK3CAMAPTNPC1RAB9AKMT2A | |
| SCHEMBL14980960 | 0.77 | RAF1 (0.76) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2677541 | 0.76 | CSF1R (0.68) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2676171 | 0.75 | BRAF (0.64) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL2676174 | 0.75 | BRAF (0.64) | RAF1BRAFCSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144062-A1 | CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE | NOVARTIS AG (CH) | 2008-11-27 | — | — | WO | disclosed |