Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mesalamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.81 |
| ▸ | ALOX5 known ✓ | P09917 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | THRB | P10828 | 2/20 | 0.81 |
| ▸ | RECQL | P46063 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.81 |
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | KDR | P35968 | 2/20 | 0.81 |
| ▸ | TNF | P01375 | 1/20 | 0.81 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.81 |
| ▸ | CASP1 | P29466 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.81 |
| ▸ | CASP7 | P55210 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mesalamine SCHEMBL28077836 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL1967328 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL31297 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL29354798 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL7579516 | 0.89 | KDM4E (0.81) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL10493008 | 0.88 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL2680533 | 0.88 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL9688231 | 0.88 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL6517036 | 0.88 | MEN1 (0.96) | KDM4EALDH1A1MEN1KMT2ACYP3A4 | |
| Mesalamine SCHEMBL2679950 | 0.88 | KDM4E (0.96) | KDM4EALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609927-B2 | Caveolin 1-reporter protein knock-in mouse | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120060232-A1 | Caveolin 1-Reporter Protein Knock-In Mouse | TRUSTEES OF DARTMOUTH COLLEGE | 2012-03-08 | — | — | US | disclosed |
| WO-2010138397-A1 | CAVEOLIN 1-REPORTER PROTEIN KNOCK-IN MOUSE | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2010-12-02 | — | — | WO | disclosed |
| US-7399902-B2 | Mouse cardiac conduction system model | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-07-15 | — | — | US | disclosed |
| EP-1836496-A2 | METHODS AND COMPOSITIONS FOR PROTEIN-HYDROXY APATITE COMPLEXES AND THEIR APPLICATION IN TESTING AND MODULATING IMMUNOLOGICAL SYSTEM INCLUDING A NOVEL IN VITRO TEST FOR THE DETECTION OF ANTIBODIES AGAINST CALCIUM BINDING PROTEIN-HYDROXY APATITE COMPLEXES | Nanobac Life Sciences (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20070141055-A1 | Methods and compositions for protein-hydroxy apatite complexes and their application in testing and modulating immunological system including a novel in vitro test for the detection of antibodies against calcium binding protein-hydroxy apatite complexes | CIFTCIOGLU, NEVA DR. | 2007-06-21 | — | — | US | disclosed |
| US-20060168674-A1 | Mouse cardiac conduction system model | UNIVERSITE DE LA MEDITERRANEE (FR) | 2006-07-27 | — | — | US | disclosed |
| US-7074611-B2 | Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof | GIE-CERBN, CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET EN MEDECINE (GIE) (FR) | 2006-07-11 | — | — | US | disclosed |
| WO-2006052924-A2 | METHODS AND COMPOSITIONS FOR PROTEIN-HYDROXY APATITE COMPLEXES AND THEIR APPLICATION IN TESTING AND MODULATING IMMUNOLOGICAL SYSTEM INCLUDING A NOVEL IN VITRO TEST FOR THE DETECTION OF ANTIBODIES AGAINST CALCIUM BINDING PROTEIN-HYDROXY APATITE COMPLEXES | NANOBAC LIFE SCIENCES (US) | 2006-05-18 | — | — | WO | disclosed |
| EP-1383891-B1 | METHOD FOR THE STABLE INVERSION OF DNA SEQUENCE BY SITE-SPECIFIC RECOMBINATION AND DNA VECTORS AND TRANSGENIC CELLS THEREOF | GIE CERBM (FR) | 2005-12-14 | — | — | EP | disclosed |
| CN-1147855-A | Determination of analytes | CORTECS LTD (GB) | 1997-04-16 | — | — | CN | disclosed |
| CN-1144560-A | analyte detection method | CORTECS LTD (GB) | 1997-03-05 | — | — | CN | disclosed |
| EP-0753149-A1 | DETECTION OF ANALYTES | CORTECS LIMITED (GB) | 1997-01-15 | — | — | EP | disclosed |
| EP-0753150-A1 | DETECTION OF ANALYTES | CORTECS LIMITED (GB) | 1997-01-15 | — | — | EP | disclosed |
| US-5506111-A | REACTING SAMPLE WITH SOLID PHASE AND LABELLED ANTIBODIES TO DIFFERENT EPITOPES OF HUMAN OSTEOCALCIN TO FORM COMPLEX, SEPARATING COMPLEX, MEASURING AMOUNT OF LABELLED ANTIBODY THEREIN, CORRELATING WITH AMOUNT OF OSTEOCALCIN PRESENT | TEIJIN LIMITED (JP) | 1996-04-09 | — | — | US | disclosed |
| WO-1995026504-A1 | DETECTION OF ANALYTES | CORTECS LIMITED (GB) | 1995-10-05 | — | — | WO | disclosed |
| WO-1995026503-A1 | DETECTION OF ANALYTES | CORTECS LIMITED (GB) | 1995-10-05 | — | — | WO | disclosed |
| EP-0646794-A1 | Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it | TEIJIN LIMITED (JP) | 1995-04-05 | — | — | EP | disclosed |
| EP-0638175-A1 | IN VITRO TEST FOR HELICOBACTER PYLORI | AUSPHARM INTERNATIONAL LIMITED (AU) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993022682-A1 | IN VITRO TEST FOR HELICOBACTER PYLORI | AUSPHARM INTERNATIONAL LIMITED (AU) | 1993-11-11 | — | — | WO | disclosed |