Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.62 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984042 | 0.82 | SMN1; SMN2 (0.66) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL3976303 | 0.81 | SMN1; SMN2 (0.60) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL3972793 | 0.79 | SMN1; SMN2 (0.57) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL3979549 | 0.77 | SMN1; SMN2 (0.59) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3973655 | 0.76 | SMN1; SMN2 (0.58) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2826602 | 0.76 | SMN1; SMN2 (0.57) | RAB9ANPC1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2827567 | 0.75 | SMN1; SMN2 (0.56) | RAB9ANPC1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2828631 | 0.74 | SMN1; SMN2 (0.55) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL4993591 | 0.73 | SMN1; SMN2 (0.54) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL17107110 | 0.73 | NPC1 (0.58) | RAB9ANPC1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242709-A1 | 2-AMIDO-4-ISOXAZOLYL THIAZOLE COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | GENENTECH, INC. | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242709-A1 | 2-AMIDO-4-ISOXAZOLYL THIAZOLE COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | ATP5ME, ATP5MG, ATP5MK | RAB9A 3471/4885NPC1 2067/4885KMT2A 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.