Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | ICMT | O60725 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320074 | 0.77 | MAPK8 (0.37) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13609217 | 0.74 | MAPK8 (0.35) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13854152 | 0.74 | MC4R (0.38) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13745617 | 0.73 | CDK8 (0.38) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13746752 | 0.71 | KIT (0.35) | MAPK8MAPK9MAPK10 | |
| SCHEMBL13745553 | 0.71 | CYP2A6 (0.35) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13745786 | 0.71 | ABL1 (0.35) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL3347936 | 0.69 | PDGFRB (0.43) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL13609260 | 0.58 | MAP4K1 (0.37) | MAPK8MAPK9MAPK10PDGFRBPDGFRA | |
| SCHEMBL1487582 | 0.57 | DGAT1 (0.42) | MAPK8MAPK9MAPK10PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |