Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP5K1C | O60331 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067955 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL5953099 | 0.81 | KMT2A (0.43) | PIP5K1CSMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14032075 | 0.76 | CYP1A2 (0.54) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL5953096 | 0.73 | PIP5K1C (0.44) | PIP5K1CSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5953301 | 0.72 | MAPK1 (0.54) | PIP5K1CLMNAMAPT | |
| SCHEMBL5952946 | 0.72 | PIP5K1C (0.42) | PIP5K1CSMN1; SMN2NPC1LMNATP53 | |
| SCHEMBL5952249 | 0.72 | MAPK1 (0.41) | PIP5K1CNPC1 | |
| SCHEMBL14032049 | 0.72 | GPBAR1 (0.42) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1000934 | 0.71 | GPX4 (0.63) | TRPV1KMT2A | |
| SCHEMBL14032052 | 0.71 | KMT2A (0.44) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |