Sugi Predict

Sugi Predict / Targets / GPX4

GPX4

Phospholipid hydroperoxide glutathione peroxidase GPX4 · P36969 · GPX4 on Sugi Atlas →

5,661 patent compounds predicted against GPX4, 3,297 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2255562 SCHEMBL2255562 0.51 16/20
SCHEMBL1568334 SCHEMBL1568334 0.54 8/20
SCHEMBL3128380 SCHEMBL3128380 0.46 8/20
SCHEMBL917195 SCHEMBL917195 0.69 7/20
SCHEMBL4140678 SCHEMBL4140678 0.48 6/20
SCHEMBL3263282 SCHEMBL3263282 0.58 5/20
SCHEMBL4152763 SCHEMBL4152763 0.57 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL4152568) 0.56 5/20
SCHEMBL5013970 SCHEMBL5013970 0.54 5/20
SCHEMBL2056217 SCHEMBL2056217 0.54 5/20
SCHEMBL916649 SCHEMBL916649 0.48 5/20
SCHEMBL3263286 SCHEMBL3263286 0.54 4/20
SCHEMBL5010693 SCHEMBL5010693 0.53 4/20
SCHEMBL5013039 SCHEMBL5013039 0.53 4/20
SCHEMBL916475 SCHEMBL916475 0.48 4/20
SCHEMBL4161565 SCHEMBL4161565 0.48 4/20
SCHEMBL3296318 SCHEMBL3296318 0.47 4/20
SCHEMBL3296323 SCHEMBL3296323 0.47 4/20
SCHEMBL916798 SCHEMBL916798 0.40 4/20
SCHEMBL977897 SCHEMBL977897 0.39 4/20

Clinical trials — most relevant to GPX4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children PHASE4UNKNOWN
Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block PHASE4UNKNOWN
The Prognostic Impact of Selenium On Critical Surgical Patients PHASE4COMPLETED
Role of Vitamin E in Gaucher Disease Patients PHASE3COMPLETED
Evaluation of The Effect of Rutin and Vitamin C on the Oxidative Stress in Hemodialysis Patients PHASE3UNKNOWN
Cysteine Supplementation in Critically Ill Neonates PHASE2/PHASE3UNKNOWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
Effects of High-dose Intravenous Selenium (Selenase®) in Adult Patients Subjected to Elective All-cause Heart Surgery PHASE3COMPLETED
Beneficial Effect of Silymarin in Ulcerative Colitis PHASE2RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial PHASE2COMPLETED
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy PHASE2RECRUITING
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta PHASE1COMPLETED
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels PHASE1COMPLETED
The Effect of Manual Lymph Drainage in Fibromyalgia Patients EARLY_PHASE1ENROLLING_BY_INVITATION
Identification of Serum Level of Glutathione Peroxidase 4 nanNOT_YET_RECRUITING
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood nanNOT_YET_RECRUITING
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis nanNOT_YET_RECRUITING
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma nanCOMPLETED
Consumption of Apple Juice in Hemodialysis Patients nanCOMPLETED
Multifaceted Analysis of the Adaptation of Rowers in the Process of Sports Training nanCOMPLETED
Prevention of Chronic Lung Disease (CLD - Prevention Study) nanNOT_YET_RECRUITING
Antioxidant Signature in Adult Patients With Phenylketonuria nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport. nanCOMPLETED
Effect of Protein on Endoplasmic Reticulum Stress nanNOT_YET_RECRUITING
Effect of Hyperbaric Therapy on Markers of Oxidative Stress in Children With Autism nanCOMPLETED
Markers of Oxidative Stress Diastolic Dysfunction nanUNKNOWN
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings nanNOT_YET_RECRUITING
Ginkgo Biloba Extract for Schizophrenia nanCOMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GPX4 binder may also engage these)

ProteinNameSimilarity
Q4AEH2 — 1.000 Q4AEH2 →
Q4AEG9 — 1.000 Q4AEG9 →
Q32QL6 — 1.000 Q32QL6 →
Q4AEH0 — 0.998 Q4AEH0 →
P36968 — 0.997 P36968 →
O70325 — 0.997 O70325 →
P36970 — 0.992 P36970 →
Q9N2J2 — 0.991 Q9N2J2 →
Q4AEH1 — 0.989 Q4AEH1 →
Q5RFG3 — 0.972 Q5RFG3 →
P46412 — 0.971 P46412 →
Q4AEH5 — 0.969 Q4AEH5 →
P18283 — 0.968 P18283 →
Q4AEH4 — 0.967 Q4AEH4 →
P23764 — 0.966 P23764 →
P37141 — 0.965 P37141 →
P22352 — 0.965 P22352 →
Q4AEH3 — 0.964 Q4AEH3 →
Q4AEH9 — 0.964 Q4AEH9 →
O46607 — 0.963 O46607 →
P11352 — 0.963 P11352 →
Q8L910 — 0.962 Q8L910 →
Q4AEH7 — 0.961 Q4AEH7 →
Q9JHC0 — 0.961 Q9JHC0 →
P21765 — 0.960 P21765 →
Q4AEI0 — 0.960 Q4AEI0 →
Q0EF98 — 0.959 Q0EF98 →
Q4AEH8 — 0.958 Q4AEH8 →
P04041 — 0.958 P04041 →
Q91WR8 — 0.957 Q91WR8 →