Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14032076 | 0.91 | HPSE (0.48) | HPSETRPV1KDM4EMEN1CYP1A2 | |
| SCHEMBL14031950 | 0.91 | NPC1 (0.46) | HPSETRPV1KDM4EMEN1KMT2A | |
| SCHEMBL14032114 | 0.90 | SMN1; SMN2 (0.47) | HPSETRPV1KDM4EKMT2ANPC1 | |
| SCHEMBL14032050 | 0.88 | POLB (0.44) | HPSETRPV1MEN1POLBKMT2A | |
| SCHEMBL14032075 | 0.87 | CYP1A2 (0.54) | HPSETRPV1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL14032053 | 0.86 | MAPT (0.58) | TRPV1KDM4EMEN1POLBKMT2A | |
| SCHEMBL14031953 | 0.86 | HPSE (0.40) | HPSETRPV1KDM4EMEN1CYP1A2 | |
| SCHEMBL3457136 | 0.86 | MTHFD2 (0.41) | HPSETRPV1KDRNPC1RAB9A | |
| SCHEMBL5067955 | 0.85 | SMN1; SMN2 (0.45) | HPSEKDM4ECYP1A2POLBCYP3A4 | |
| SCHEMBL14031928 | 0.85 | HPSE (0.39) | HPSEKDM4EMEN1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |