MTHFD2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5370174	0.73	9/20
SCHEMBL415023	0.52	8/20
SCHEMBL5647451	0.50	8/20
SCHEMBL3118565	0.50	7/20
SCHEMBL2987838	0.54	6/20
Ethylene (SCHEMBL8381019)	0.51	6/20
SCHEMBL2408052	0.50	6/20
SCHEMBL1033822	0.54	5/20
SCHEMBL9042720	0.47	5/20
SCHEMBL2442034	0.42	5/20
SCHEMBL7783581	0.48	4/20
SCHEMBL2471575	0.46	4/20
SCHEMBL1034182	0.46	4/20
SCHEMBL2410631	0.46	4/20
SCHEMBL2410478	0.45	4/20
SCHEMBL2407042	0.41	4/20
SCHEMBL2406140	0.40	4/20
SCHEMBL188064	0.61	3/20
SCHEMBL258924	0.61	3/20
SCHEMBL3181068	0.61	3/20

Clinical trials — most relevant to MTHFD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
China Stroke Primary Prevention Trial	PHASE4	COMPLETED
Homocysteine After Nitrous Oxide Anesthesia	PHASE4	COMPLETED
B Vitamins in MTHFR Positive Patients With Major Depression: A Post Hoc Analysis of Findings	PHASE4	COMPLETED
Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis	PHASE4	UNKNOWN
A Study of PTC923 in Participants With Phenylketonuria	PHASE3	COMPLETED
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	PHASE2/PHASE3	UNKNOWN
Folate Rechallenge	PHASE2	COMPLETED
Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study	PHASE2	UNKNOWN
Capecitabine as Second-Line Therapy in Treating Patients With Stage IV Pancreatic Cancer Who Have the Thymidylate Synthase Gene	PHASE2	COMPLETED
A Study to Assess CH1504 in Patients With Active Rheumatoid Arthritis	PHASE2	COMPLETED
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE1	COMPLETED
A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure	PHASE1	COMPLETED
Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS)	PHASE1	WITHDRAWN
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial	nan	NOT_YET_RECRUITING
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization	nan	COMPLETED
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer	nan	COMPLETED
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524	nan	COMPLETED
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients	nan	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant Women	nan	RECRUITING
C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer	nan	UNKNOWN
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy	nan	COMPLETED
Where is the Initial Site of Biotransformation of Folates in Humans?	nan	COMPLETED
Optimal Nutrition for Prevention of Hypertension in Pregnancy	nan	ACTIVE_NOT_RECRUITING
Folic Acid Supplementation in Women of Child Bearing Age	nan	COMPLETED
Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study	nan	COMPLETED
Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study	nan	COMPLETED
Study of Homocysteine Metabolism in Homocystinuria	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MTHFD2 binder may also engage these)

Protein	Name	Similarity
Q0P5C2	—	1.000	Q0P5C2 →
P18155	—	0.998	P18155 →
D3YZG8	—	0.998	D3YZG8 →
Q5ZKA5	—	0.996	Q5ZKA5 →
D3ZUA0	—	0.995	D3ZUA0 →
F6ZFR0	—	0.991	F6ZFR0 →
Q9H903	—	0.991	Q9H903 →
A2RVV7	—	0.988	A2RVV7 →
P29696	—	0.987	P29696 →
Q04448	—	0.986	Q04448 →
Q9VWH4	—	0.984	Q9VWH4 →
Q9D6R2	—	0.984	Q9D6R2 →
Q1MPZ8	—	0.984	Q1MPZ8 →
Q1KLZ1	—	0.984	Q1KLZ1 →
Q8BPC6	—	0.984	Q8BPC6 →
P56471	—	0.983	P56471 →
Q28480	—	0.983	Q28480 →
A0A7J6G7L9	—	0.983	A0A7J6G7L9 →
P41563	—	0.983	P41563 →
P11725	—	0.983	P11725 →
Q8TB37	—	0.983	Q8TB37 →
Q9Z2I8	—	0.983	Q9Z2I8 →
Q58CP0	—	0.982	Q58CP0 →
Q8LFC0	—	0.982	Q8LFC0 →
Q5RBT4	—	0.982	Q5RBT4 →
IDH3A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	0.982	landscape →
Q2GLF2	—	0.982	Q2GLF2 →
Q92210	—	0.982	Q92210 →
Q28479	—	0.982	Q28479 →
Q9XFS9	—	0.982	Q9XFS9 →