Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13308352 | 0.87 | OPRK1 (0.59) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL8574805 | 0.86 | OPRK1 (0.56) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL8574802 | 0.86 | OPRK1 (0.56) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL31535467 | 0.86 | OPRK1 (0.55) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL334581 | 0.85 | OPRK1 (0.59) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL6343378 | 0.85 | OPRK1 (0.59) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL1714279 | 0.85 | OPRK1 (0.59) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL6717771 | 0.83 | OPRK1 (0.57) | OPRK1HDAC6HDAC1HDAC8KMT2A | |
| SCHEMBL876552 | 0.83 | HDAC6 (0.73) | OPRK1HDAC6HDAC1HDAC8EPHX2 | |
| SCHEMBL877776 | 0.83 | HDAC6 (0.73) | OPRK1HDAC6HDAC1HDAC8EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |