Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.63 |
| ▸ | LSS | P48449 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20460249 | 0.85 | LTA4H (0.65) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL16204295 | 0.85 | LTA4H (0.65) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL8476224 | 0.84 | LTA4H (0.63) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL29129692 | 0.83 | HRH3 (0.58) | LTA4HLSSCYP1A2HRH3KDM4E | |
| SCHEMBL13305547 | 0.83 | LTA4H (0.62) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL20460282 | 0.83 | LTA4H (0.66) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL1405661 | 0.80 | LTA4H (0.85) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL13305558 | 0.80 | CHRM2 (0.64) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL17164698 | 0.80 | LTA4H (0.58) | LTA4HLSSLMNACYP2D6HTR6 | |
| SCHEMBL13305563 | 0.80 | LTA4H (0.59) | LTA4HLSSLMNACYP2D6HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |