Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 13/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033306 | 1.00 | S1PR3 (0.43) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL4602819 | 0.84 | S1PR3 (0.43) | S1PR3S1PR1S1PR4S1PR2MEN1 | |
| SCHEMBL14033749 | 0.84 | S1PR3 (0.51) | S1PR3S1PR4S1PR2NPC1RAB9A | |
| SCHEMBL14033932 | 0.84 | S1PR3 (0.51) | S1PR3S1PR4S1PR2NPC1RAB9A | |
| SCHEMBL23716350 | 0.81 | S1PR3 (0.55) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL14033601 | 0.81 | S1PR3 (0.45) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL14033902 | 0.80 | TRPV1 (0.39) | S1PR3S1PR1S1PR4S1PR2 | |
| SCHEMBL14033813 | 0.80 | TRPV1 (0.39) | S1PR3S1PR1S1PR4S1PR2 | |
| SCHEMBL4603195 | 0.77 | S1PR3 (0.40) | S1PR3S1PR1S1PR4S1PR2MEN1 | |
| SCHEMBL14585677 | 0.77 | S1PR3 (0.40) | S1PR3S1PR1S1PR4S1PR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |