Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 15/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23716352 | 0.82 | S1PR3 (0.52) | S1PR3S1PR1S1PR4S1PR2GBA1 | |
| SCHEMBL14033306 | 0.81 | S1PR3 (0.43) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL14033593 | 0.81 | S1PR3 (0.43) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL23609159 | 0.79 | S1PR3 (0.48) | S1PR3S1PR1S1PR4S1PR2ADRB2 | |
| SCHEMBL17842327 | 0.79 | FFAR2 (0.42) | S1PR3S1PR1S1PR4S1PR2ADRB2 | |
| SCHEMBL14033601 | 0.79 | S1PR3 (0.45) | S1PR3S1PR1S1PR4S1PR2NPC1 | |
| SCHEMBL23609157 | 0.76 | S1PR3 (0.40) | S1PR3S1PR1S1PR4S1PR2ADRB2 | |
| Hydrochloric Acid SCHEMBL4692880 | 0.73 | ESR1 (0.42) | S1PR3S1PR1S1PR4S1PR2ADRB2 | |
| SCHEMBL10557226 | 0.71 | SLC6A2 (0.51) | S1PR3S1PR1ADRB2 | |
| SCHEMBL27614753 | 0.71 | SLC6A2 (0.46) | S1PR3S1PR1NPC1RAB9AGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |