Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702236 | 0.84 | PDE4A (0.53) | PDE4APDE4BNPSR1SMN1; SMN2PDE4C | |
| SCHEMBL14034049 | 0.83 | PDE4B (0.42) | PDE4APDE4BNPSR1SMN1; SMN2RAB9A | |
| SCHEMBL16951534 | 0.77 | RAB9A (0.40) | PDE4APDE4BNPSR1SMN1; SMN2RAB9A | |
| SCHEMBL4818551 | 0.76 | PPARG (0.51) | PDE4APDE4BSMN1; SMN2PDE4CPDE4D | |
| SCHEMBL1143446 | 0.75 | PDE4A (0.45) | PDE4APDE4BNPSR1SMN1; SMN2RAB9A | |
| SCHEMBL4819752 | 0.74 | SMPD1 (0.51) | PDE4APDE4BNPSR1SMN1; SMN2RAB9A | |
| SCHEMBL1765748 | 0.74 | HIF1A (0.45) | PDE4APDE4BNPSR1RAB9APDE4C | |
| SCHEMBL7371299 | 0.72 | TSHR (0.63) | PDE4APDE4BNPSR1RAB9APDE4C | |
| SCHEMBL16956686 | 0.72 | MAPT (0.46) | PDE4BNPSR1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL4826116 | 0.72 | PDE4A (0.51) | PDE4APDE4BNPSR1SMN1; SMN2PDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |