Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | THPO | P40225 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16226979 | 1.00 | HRH3 (0.43) | HRH3DPP4ACHEOPRM1OPRD1 | |
| SCHEMBL14033868 | 0.87 | CYP2D6 (0.49) | HRH3DPP4OPRM1OPRD1SLC6A2 | |
| SCHEMBL26673752 | 0.87 | HRH3 (0.46) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| SCHEMBL6874564 | 0.84 | HRH3 (0.42) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| SCHEMBL27048362 | 0.81 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| SCHEMBL21831282 | 0.81 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| SCHEMBL27048103 | 0.81 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL27033977 | 0.80 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL27130665 | 0.80 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL27033984 | 0.80 | HRH3 (0.43) | HRH3ACHEOPRM1OPRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1423381-B1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES | SCHERING CORP (US) | 2007-01-03 | — | — | EP | disclosed |