Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.40 |
| ▸ | GCGR | P47871 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033947 | 0.81 | ALDH1A1 (0.40) | TDP1MAPK14HPGDALDH1A1 | |
| SCHEMBL5104334 | 0.77 | MAPK14 (0.54) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5097721 | 0.77 | RIPK3 (0.52) | TDP1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL15452371 | 0.74 | TDP1 (0.76) | TDP1HPGDALDH1A1POLBL3MBTL1 | |
| SCHEMBL5104405 | 0.71 | MAPK14 (0.43) | MAPK14GCGRALDH1A1MAPK13MAPK12 | |
| SCHEMBL5091913 | 0.70 | MAPK14 (0.54) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL5640212 | 0.70 | MAPK14 (0.41) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL14033245 | 0.70 | MAPK14 (0.54) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL4474345 | 0.68 | CA12 (0.61) | MAPK14GCGRHPGDALDH1A1L3MBTL1 | |
| SCHEMBL5098251 | 0.67 | MAPK14 (0.48) | TDP1MAPK14GCGRPOLBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |